This workshop brings together researchers from various disciplines investigating the biology and biophysics of postsynaptic domains, with a focus on quantitative aspects. The aim is to expand on the current knowledge about excitatory and inhibitory synapse size and its regulation, and to discuss future avenues for an improved quantitative understanding of the underlying mechanisms, ranging from trans-synaptic signaling and receptor and scaffold-protein aggregation to local protein synthesis.
Registration is free but mandatory. Poster presentations are welcome.
Programme
Day 1 – Thursday, November 14 Salle Favard, 46 rue d’Ulm
13:30 Welcome & coffee
14:00 Opening remarks
14:10 - 18:00 Talks & discussion
Christian Specht (UPSaclay, Le Kremlin-Bicêtre): Quantitative single-molecule imaging of synaptic proteins: not more, not less
Jonas Ranft (ENS-PSL, Paris): Modeling receptor-scaffold dynamics at inhibitory synapses
Matthieu Letellier (U Bordeaux): Molecular diversification of hippocampal synapses
15:50 - 16:20 Coffee break
Dilja Krueger-Burg (U Mainz): Diversity of GABAergic postsynaptic complexes in health and disease
Marianne Renner (Sorbonne U, IFM, Paris): Simulating and analyzing the effects of self-crowding in synapses
18:00 - 19:30 Poster session & refreshments
Day 2 – Friday, November 15 Salle Marbo, 29 rue d’Ulm
08:45 Welcome & coffee
09:00 - 13:00 Talks & discussion
Hans Maric (U Würzburg): Probing the fractional occupancy of synaptic binding sites
Jean-Louis Bessereau (U Lyon): Specification of postsynaptic identity by extracellular matrix proteins
10:40 - 11:10 Coffee break
Tatjana Tchumatchenko (U Bonn): Energy and dynamics of synapses
General discussion
13:00 Closing remarks & end
Organisation
Jonas Ranft (IBENS, ENS-PSL & CNRS, Paris) Vincent Hakim (LPENS, ENS-PLS & CNRS, Paris) Christian Specht (UPSaclay, Inserm, Le Kremlin-Bicêtre)
Acknowledgments
We thank the Mission pour les Initiatives Transverses et Interdisciplinaires (MITI) of the CNRS for financial support.
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